The entorhinal cortex (EC) is an area of the brain’s allocortex, located in the medial temporal lobe, whose functions include being a widespread network hub for memory, navigation, and the perception of time. The EC is the main interface between the hippocampus and neocortex.

What does the entorhinal cortex do?

The entorhinal cortex is the gateway for information entering and leaving the hippocampal formation. The entorhinal cortex is a component of the medial temporal lobe memory system, although it is increasingly believed to have a perceptual function (Baxter, 2009; Suzuki, 2009).

What is entorhinal cortex and hippocampus?

The entorhinal cortex (EC)–hippocampal (HPC) network plays an essential role for episodic memory, which preserves spatial and temporal information about the occurrence of past events. Episodic memory enables us to remember where and when a distinct sequence of events occurred in our past.

Is entorhinal cortex part of temporal lobe?

The entorhinal cortex is part of the medial temporal lobe or hippocampal memory system and constitutes the major gateway between the hippocampal formation and the neocortex.

What are the main functions of the hippocampus?

The hippocampus is thought to be principally involved in storing long-term memories and in making those memories resistant to forgetting, though this is a matter of debate. It is also thought to play an important role in spatial processing and navigation.

Is the entorhinal cortex part of the hippocampal formation?

What is the perforant path in psychology?

Perforant path. In the brain, the perforant path or perforant pathway, provides a connectional route from the entorhinal cortex to all fields of the hippocampal formation, including the dentate gyrus, all CA fields (including CA1), and the subiculum . Though it arises mainly from entorhinal layers II and III, the perforant path comprises…

What is the perforant pathway in the rat hippocampus?

In rats, pyramidal and stellate cells in layer II of entorhinal cortex project through the subiculum of the hippocampus, giving rise to the name “perforant pathway”. These glutamatergic fibers form a laminar pattern and terminate in the dentate gyrus and cornu ammonis 3 (CA3) region of the hippocampus.

What happens to the direct perforant path input to the CA1?

“Disruption of the direct perforant path input to the CA1 subregion of the dorsal hippocampus interferes with spatial working memory and novelty detection”. Behavioural Brain Research. 189 (2): 273–83. doi: 10.1016/j.bbr.2008.01.002.