Dantrolene is used to treat spasticity (muscle stiffness and tightness) or muscle spasms associated with spinal cord injuries, stroke, multiple sclerosis, or cerebral palsy.

What is dantrolene the antidote for?

The first volume provides an introduction to the series and reviews three antidotes: naloxone, a specific opioid antagonist used in the treatment of opiate poisoning; flumazenil, used to reverse the sedative, anti-convulsant and muscle-relaxant effects of benzodiazepines; and dantrolene sodium, used in the treatment of …

Is dantrolene a strong muscle relaxant?

Dantrolene is classified as a direct-acting skeletal muscle relaxant. It is currently the only specific and effective treatment for malignant hyperthermia.

How does dantrolene sodium work?

Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. It achieves this by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.

Is dantrolene a reversal agent?

No reversal drug or antidote exists for IV or oral dantrolene. For hepatotoxicity induced by oral dantrolene, discontinue the medication, and initiate symptomatic therapy.

Can dantrolene cause seizures?

On dantrolene sodium suspension, there was no persistent change in these parameters. Therefore, it is concluded that dantrolene sodium does not adversely affect the frequency of seizures in children with epilepsy and spasticity, who are being maintained on anticonvulsant medications.

Does dantrolene cause hyperkalemia?

When used with calcium channel blockers (verapamil or diltiazem), dantrolene may produce life-threatening hyperkalemia and myocardial depression. Otherwise there does not appear to be significant negative interaction with other drugs.

How long does sanctura take to work?

Sanctura (trospium) may improve symptoms from overactive bladder in as little as a week. Generally, you should expect to see significantly fewer symptoms by the third month of Sanctura. If your symptoms do not improve or worsen during this time period, talk to your doctor about altering your dosage.

What is the chemical formula for Dantrium?

Dantrium is classified as a direct-acting skeletal muscle relaxant. Chemically, Dantrium is hydrated 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione sodium salt. The structural formula for the hydrated salt is:

What is the pH of a Dantrium injection?

Dantrium Intravenous is supplied in 70 mL vials containing 20 mg dantrolene sodium, 3000 mg mannitol, and sufficient sodium hydroxide to yield a pH of approximately 9.5 when reconstituted with 60 mL sterile water for injection USP (without a bacteriostatic agent).

How do I report side effects of Dantrium intravenous?

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Dantrium Intravenous is a sterile, non-pyrogenic, lyophilized formulation of dantrolene sodium for injection.

What is the function of Dantrium in muscle relaxation?

In isolated nerve-muscle preparation, Dantrium has been shown to produce relaxation by affecting the contractile response of the muscle at a site beyond the myoneural junction. In skeletal muscle, Dantrium dissociates the excitation-contraction coupling, probably by interfering with the release of Ca++ from the sarcoplasmic reticulum.