A positive Z-score (number of standard deviations) more than 2.0 SD above the reference range indicates a high IGF-1 level suggestive of acromegaly. A Z-score within 2.0 SD above or below the reference range indicates normal levels of IGF-1.

What does IGF-1 tell you?

What is an IGF-1 test? This test measures the amount of IGF-1 (insulin-like growth factor 1) in your blood. IGF-1 is a hormone that manages the effects of growth hormone (GH) in your body. Together, IGF-1 and GH promote normal growth of bones and tissues.

How is IGF-1 measured?

IGF-1 measurements are adjusted for age because levels tend to decrease after puberty as you get older. Results of IGF-1 are given in nanograms per milliliter (ng/mL).

What is the difference between GH and IGF-1?

The metabolic effects of these two hormones, however, are different. Whereas GH treatment leads to elevated insulin and glucose levels, reduced insulin sensitivity, and impaired glucose tolerance, IGF-I treatment leads to reduced insulin and GH levels and enhanced insulin sensitivity.

What does low IGF-1 indicate?

Decreased IGF-1 If the IGF-1 level is decreased, then it is likely that there is a GH deficiency or an insensitivity to GH. If this is in a child, the GH deficiency may have already caused short stature and delayed development and may be treated with GH supplementation.

What are the benefits of IGF-1?

WHAT MAY BE THE BENEFITS OF IGF-1/LR3

• Muscle hypertrophy effects.
• Conserves muscle in heifers.
• Increase lean muscle mass.
• Improve athletic performance.
• Improve muscle recovery after workouts.
• Reduce recovery time after injuries.
• Boost muscle protein synthesis.
• Reduce Body Fat.

How is IGF-1 produced?

IGF-1 is produced primarily by the liver. Production is stimulated by growth hormone (GH). Most of IGF-1 is bound to one of 6 binding proteins (IGF-BP).

What means IGF?

Insulin-like growth factor
A protein made by the body that stimulates the growth of many types of cells. Insulin-like growth factor is similar to insulin (a hormone made in the pancreas). Insulin-like growth factor is a type of growth factor and a type of cytokine. Also called IGF and somatomedin.

What is the role of IGF?

insulin-like growth factor (IGF), formerly called somatomedin, any of several peptide hormones that function primarily to stimulate growth but that also possess some ability to decrease blood glucose levels. The major action of IGFs is on cell growth.

What are the side effects of IGF-1?

Some possible side effects with IGF-1/LR3 could be:

• Joint pain.
• Muscle pain.
• Headaches.
• Nausea.
• Hypoglycemia.
• May be associated with an increased risk of developing a number of common cancers, including lung, breast, colorectal, and prostate.

What is measuring IGF-1 used for?

Measuring IGF-1 is useful in assessing and managing growth-related disorders. For example, acromegaly (growth hormone [GH] excess) causes elevated levels of IGF-1.

What is the relationship between IGF-1 levels and acromegaly?

In managing GH disorders, age-normalized serum IGF-1 values signify that Acromegaly is controlled, 1 whereas elevated values indicate that acromegaly is not controlled.

What is the significance of the wild-type concentration of IGF-1?

The wild-type concentration only represents half the circulating IGF-1 for heterozygous individuals. The absence of wild type IGF-1 can be explained by the individual being homozygous for the variant or heterozygous for 2 different variants. In either case, these variants have unclear clinical significance.

What is a normal IGF-1 z score?

A Z-score within 2.0 SD above or below the reference range indicates normal levels of IGF-1. This result may exclude acromegaly (such as in patients with a pituitary mass). 1 However individuals with GHD may have normal IGF-1 levels (such as those with an increased BMI). 2,3